Sameer Sheth, M.D., Ph.D. Bio

Assistant Professor of Neurosurgery
Columbia University Medical Center
New York Presbyterian Hospital

710 West 168th Street
Neurological Institute 427
NY, NY 10032

Phone: 646-317-4638
Fax: 212-305-4828
Email: ss4451@columbia.edu

EDUCATION
Fellowship in Functional and Stereotactic Neurosurgery: Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Residency in Neurological Surgery: Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Internship in General Surgery: Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Medical School (MD): David Geffen School of Medicine at UCLA, Los Angeles, California
Graduate School (PhD in Neuroscience): University of California Los Angeles, Los Angeles, California
Undergraduate (BA in Physics and Astronomy & Astrophysics, summa cum laude): Harvard University, Cambridge, MA

ACADEMIC APPOINTMENTS
Instructor, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

HONORS AND AWARDS
2013 Runner Up, American Academy of Neurological Surgery Award
2012 Philip L. Gildenberg Award, 2012 AANS annual meeting
2012 Two Plenary Session platform presentation, 2012 AANS annual meeting
2012 Harvard Medical School Resident Teaching Award
2011 Integra Foundation Award, 2011 AANS annual meeting
2011 Plenary Session platform presentation, 2011 AANS annual meeting
2010 Best Paper, Neurology Category, 2010 Neurological Society of India (NSI)-CNS joint meeting
2010 Best Clinical Research Award for Residents/Fellows, 2010 ASSFN annual meeting
2010 Second Place, Stereotactic/Functional Award, 2010 AANS annual meeting
2009 Sherry Apple Resident Travel Scholarship, 2009 CNS annual meeting
2007 Stereotactic and Functional Neurosurgery Resident Award, 2007 CNS annual meeting
2002 Organization for Human Brain Mapping conference travel fellowship
1997 Harvard College Scholarship
1996 John Harvard Scholarship

FELLOWSHIPS AND GRANTS
2013 – 2015 Dana Foundation Clinical Neuroscience Research Program, “Investigating the role of medial and lateral prefrontal cortex in human decision-making

2013 Columbia University Imaging Core Usage Funding Program, “Determining the role of the dorsolateral prefrontal cortex in processing cognitive interference

2013 – 2015 NIH Neurosurgeon Research Career Development Program, “Cognitive control in the human prefrontal cortex” (K12 NS080223)

2009 – 2011 NIH Neuroscience Resident Research Program fellowship (R25 NS065743)

2010 Neurosurgery Research and Education Foundation (NREF) Fellowship, “Intraoperative Functional Brain Mapping with Optical Polarization Imaging

2009 MGH Cancer Center Grant, “Identifying Boundaries of Infiltrative Brain Tumors with Wide-Field High-Resolution Optical Polarization Imaging

2009 Harvard University Catalyst Grant, “Intraoperative Functional Brain Mapping

2002 – 2004 NIH NRSA (National Research Service Award) individual fellowship, “Assessing Neurovascular Coupling with Functional Mapping” (F30 MH67432)

2001 – 2003 NIH Training Grant in Neuroimaging fellowship (T32 MH19950)

1998 – 2005 NIH Medical Scientist Training Program fellowship (T32 GM08042)

JOURNAL PUBLICATIONS
Patel SR, Sheth SA, Martinez-Rubio C, Mian MK, Asaad WF, Gerrard JL, Kwon CS, Dougherty DD, Flaherty AW, Greenberg BD, Gale JT, Williams ZM, Eskandar EN. “Studying task-related activity of individual neurons in the human brain.” Nature Protocols 8(5):949-57 (2013).

Sheth SA, Mian MK, Patel SR, Asaad WF, Williams ZM, Dougherty DD, Bush G, Eskandar EN. “Human dorsal anterior cingulate neurons mediate ongoing behavioral adaptation.” Nature 488: 218-221 (2012).

Patel S*, Sheth SA*, Mian MK, Gale JT, Greenberg BD, Dougherty DD, Eskandar EN. “Single-neuronal responses during a financial decision making task in the human nucleus accumbens.” Journal of Neuroscience 32: 7311-7315 (2012). *Contributed equally.

Mian MK, Sheth S, Patel SR, Spiliopoulos K, Eskandar EN, Williams ZW. “Encoding of rules by neurons in the human dorsolateral prefrontal cortex.” Cerebral Cortex Nov 21 (2012 Epub ahead of print).

Sheth SA, Eskandar EN, Liker MA. “Introduction: Evolving trends in movement disorder surgery.” Neurosurgical Focus 35:5 (2013).

Karas PJ, Mikell CB, Christian E, Liker MA, Sheth SA. “Deep brain stimulation: a mechanistic and clinical update.” Neurosurgical Focus 35:5 (2013).

Sheth SA, Neal J, Tangherlini F, Mian MK, Gentil A, Cosgrove GR, Eskandar EN, Dougherty DD. “Limbic system surgery for treatment-refractory obsessive-compulsive disorder: five-year prospective follow-up in 64 patients.” Journal of Neurosurgery 118(3):491-7 (2013).

Sheth SA, Eckhardt C, Eskandar EN, Simon MV. “Factors affecting successful localization of the central sulcus using the somatosensory evoked potential phase reversal technique.” Neurosurgery 72(5):828-34 (2013).

Walcott BP, Miller JC, Kwon C-S, Sheth SA, Hiller M, Cronin CA, Schwamm LH, Simard JM Kahle KT, Kimberly WT, Sheth KN. “Outcomes in severe middle cerebral artery ischemic stroke.” Neurocritical Care (2013 Epub ahead of print).

Walcott BP, Neal JB, Sheth SA, Kahle KT, Eskandar EN, Coumans JV, Nahed BV. “The incidence of complications in elective cranial neurosurgery associated with dural closure material.” J Neurosurgery (2013 Epub ahead of print).

Venteicher AS, Walcott BP, Sheth SA, Curry WT, Nahed BV. “Clinical Features of Brain Metastasis from Salivary Gland Tumors.” J Clin Neurosci 20(11):1533-7 (2013).

Kwon CS, Sheth SA, Walcott BP, Neal J, Eskandar EN, Ogilvy CS. “Long-term seizure outcomes following resection of supratentorial cavernous malformations.” Clin Neurol Neurosurg 115(11):2377-81 (2013).

Jan TA, Redjal N, Walcott BP, Sheth SA. “Intranasal myiasis: A rare complication of transnasal skull base surgery.” J Clin Neurosci 20(8):1178-80 (2013).

Walcott BP, Sheth SA, Kwon CS, Fehnel C, Koffie RM, Asaad WF, Nahed BV, Coumans JV. “Predictors of cranioplasty complications in stroke and trauma patients” J Neurosurgery 118(4):757-62 (2013).

Yanamadala V, Sheth SA, Walcott BP, Buchbinder BR, Buckley D, Ogilvy CS. “Non-contrast 3D time-of-flight MRA for visualization of intracranial aneurysms in patients with absolute contraindications to CT or MRI contrast” J Clin Neurosci 20(8):1122-6 (2013).

Patel SR, Aronson JP, Sheth SA, Eskandar EN. “Lesion procedures in psychiatric neurosurgery.” World Neurosurgery 80(3-4):S31.e9-S31.e16 (2013).

Ryu JK, Walcott BP, Kahle KT, Sheth SA, Peterson RT, Nahed BV, Coumans JV, Simard JM. “Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury.” Neurocritical Care 19(2):222-31 (2013).

Bourne SK, Walcott BP, Sheth SA, Coumans JV. “Neurological surgery: The influence of physical and mental demands on humans performing complex operations.” J Clin Neurosci 20(3):342-8 (2013).

Walcott BP, Sheth SA, Nahed BV, Coumans JV. “Conflict of interest in spine surgery reporting.” PLoS One 7(8):e44327 (2012).

Bourne SK, Sheth SA, Neal J, Mian MK, Cosgrove GR, Eskandar EN, Dougherty DD. “Beneficial effect of subsequent lesion procedures following non-response to initial cingulotomy for severe, treatment-refractory OCD.” Neurosurgery 72(2):196-202 (2013).

Snuderl M, Wirth D, Sheth SA, Bourne SK, Kwon CS, Ancukiewicz M, Curry WT, Frosch MP, Yaroslavsky AN. “Dye-enhanced multimodal confocal imaging as a novel approach to intraoperative diagnosis of brain tumors.” Brain Pathology 23(1):73-81 (2012).

Bourne SK, Eckhardt CA, Sheth SA, Eskandar EN. “Mechanisms of deep brain stimulation for obsessive compulsive disorder: effects upon cells and circuits.” Frontiers in Integrated Neuroscience 6(29):1-14 (2012).

Sheth SA, Mian MK, Neal J, Tritos NA, Nachtigall L, Klibanski A, Biller BMK, Swearingen B. “Transsphenoidal surgery for Cushing’s disease after non-diagnostic inferior petrosal sinus sampling.” Neurosurgery 71:1 14-22 (2012).

Walcott BP, Nahed BV, Sheth SA, Caracci JR, Asaad WF. “Bilateral hemicraniectomy in non-penetrating traumatic brain injury.” Journal of Neurotrauma 29(10):1879-1885 (2012).

Wirth D, Snuderl M, Sheth SA, Kwon CS, Frosch M, Curry WT, Yaroslavsky A. “Identifying brain neoplasms using dye-enhanced multimodal confocal imaging.” Journal of Biomedical Optics 17(2):026012:1-7 (2012).

Karakis I, Velez-Ruiz N, Pathmanathan J, Sheth SA, Eskandar EN, Cole AJ. “Foramen ovale electrodes in the evaluation of epilepsy surgery: conventional and unconventional uses.” Epilepsy and Behavior 22(2):247-54 (2011).

Sheth SA, Abuelem T, Gale JT, Eskandar EN. “Basal Ganglia Neurons Dynamically Facilitate Exploration during Associative Learning.” Journal of Neuroscience 31(13):4878-4885 (2011).

Gale JT, Martinez-Rubio C, Sheth SA, Eskandar EN. “Intra-operative behavioral tasks in awake humans undergoing deep brain stimulation surgery.” Journal of Visualized Experiments 47 (2011).

Sheth SA, Mian M, Abuelem T, Gale JT, Eskandar, EN. “Facilitation of visuomotor associative motor learning by the basal ganglia.” Clinical Neurosurgery 57: 145-150 (2010).

Mian M, Campos M, Sheth SA, Eskandar EN. “Deep brain stimulation for obsessive-compulsive disorder: past, present, and future.” Neurosurgical Focus 29(2):E10 (2010).

Sheth SA, McGirt M, Woodworth G, Wang P, Rigamonti D. “Ultrasound guidance for distal insertion of ventriculo-atrial shunt catheters: technical note.” Neurology Research 31(3):280-2 (2009).

Sheth SA, Prakash N, Guiou M and Toga AW. “Validation and visualization of two-dimensional optical spectroscopic imaging of cerebral hemodynamics.” NeuroImage (Suppl 2):T36-43 (2009).

Prakash N, Uhlemann F, Sheth SA, Bookheimer S, Martin N and Toga AW. “Current trends in intraoperative optical imaging for functional brain mapping and delineation of lesions of language cortex.” NeuroImage (Suppl 2):T116-26 (2009).

Harris S, Sheth S and Cohen MS. “Functional neuroimaging of belief, disbelief, and uncertainty.” Annals of Neurology 63(2):141-7 (2008).

Prakash N, Biag J, Sheth SA, Mitsuyama S, Theriot J, Ramachandra C and Toga AW. “Temporal profiles and 2-dimensional oxy-, deoxy-, and total-hemoglobin somatosensory maps in rat versus mouse cortex.” NeuroImage 37(Suppl 1):S27-36 (2007).

Sheth SA, Nemoto M, Guiou M, Walker M and Toga AW. “Spatiotemporal evolution of functional hemodynamic changes and their relationship to neuronal activity.” Journal of Cerebral Blood Flow and Metabolism March 2: 1-12 (2005).

Fuster J, Guiou M, Ardestani A, Cannestra A, Sheth S, Zhou Y-D, Toga AW and Bodner M. “Near-infrared spectroscopy (NIRS) in cognitive neuroscience of the primate brain.” NeuroImage 26(1):215-20 (2005).

Guiou M, Sheth S, Nemoto M, Walker M, Pouratian N, Ba A and Toga AW. “Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling.” Journal of Biomedical Optics 10(1):011004:1-7 (2005).

Sheth SA, Nemoto M, Guiou M, Walker M, Pouratian N and Toga AW. “Linear and nonlinear relationships between neuronal activity, oxygen metabolism, and hemodynamic responses.” Neuron 42(2):347-355 (2004). Cover article.

Nemoto M, Sheth S, Guiou M, Pouratian N, Chen JWY and Toga AW. “Functional signal and paradigm dependent linear relationships between synaptic activity and hemodynamic responses in rat somatosensory cortex.” Journal of Neuroscience 24(15):3850-3863 (2004). Cover article.

Sheth SA, Nemoto M, Guiou M, Walker M, Pouratian N, Hageman N and Toga AW. “Columnar specificity of microvascular oxygenation and volume responses: Implications for functional brain mapping.” Journal of Neuroscience 24(3):634-641 (2004).

Sheth S, Nemoto M, Guiou M, Walker M, Pouratian N and Toga AW. “Evaluation of coupling between optical intrinsic signals and neuronal activity in rat somatosensory cortex.” NeuroImage 19(3):884-94 (2003).

Pouratian N, Sheth SA, Bookheimer SY, Martin NA and Toga AW. “Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance.” Neurosurgical Focus 15(1), Article 2: 1-8 (2003).

Pouratian N, Sheth SA, Martin NA and Toga AW. “Shedding light on brain mapping: advances in human optical imaging.” Trends in Neurosciences 26(5):277-82 (2003).

Mair RW, Hoffmann D, Sheth SA, Wong GP, Butler JP, Patz S, Topulos GP and Walsworth RL. “Reduced xenon diffusion for quantitative lung study – The Role of SF6.” NMR in Biomedicine, 13(4):229-33 (2000).

Sheth S, Liang E, Luo C and Murakami T. “ASCA Measurement of the Hydrogen Column Density to 1E 1740.7–2942.” Astrophysical Journal 468 (no.2, pt. 1):755-760 (2000).